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Octreotide API (CAS 83150-76-9) is a synthetic long-acting somatostatin analog, which is a core polypeptide active pharmaceutical ingredient for anti-tumor and tumor symptomatic treatment. With stable chemical structure and precise receptor binding properties, it functions as a key raw material for drugs treating neuroendocrine tumors, gastroenteropancreatic tumors and other diseases. As its unique chemical identifier, CAS 83150-76-9 ensures the uniqueness and traceability of Octreotide API in global R&D, production, registration and circulation.
Technical Specifications
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Product Name |
Octreotide API |
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Synonyms |
CAS 83150-76-9, Octreotide powder |
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Characteristic |
White to off-white amorphous or lyophilized powder |
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CAS Number |
83150-76-9 |
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Assay |
≥99.0% (HPLC, Subject to the COA) |
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Formula |
C49H66N10O10S2 |
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Package |
Technical Package |
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Storage |
Store at -20℃ |
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Structure |
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We cooperate deeply with GMP, FDA and CEP certified partner factories, and provide global pharmaceutical companies with Octreotide powder that complies with USP, EP and CP international pharmacopoeia standards. We support the R&D and commercialization of anti-tumor drugs with stable supply chain, strict quality control and complete registration documents. We maintain transparent and reasonable Octreotide cost and Octreotide price, and provide customers with cost-effective raw material solutions.
Product Characteristics
Octreotide API (CAS 83150-76-9) is produced through solid-phase synthesis, multi-stage preparative chromatographic purification and sterile lyophilization refining. Production, sub-packaging and sealing are fully completed in Class B/A clean areas to control risky impurities such as peptide fragments, deamidation products, oxidation products, residual solvents, heavy metals and microorganisms at the source. In terms of quality control, the assay is ≥99.0%, maximum single impurity ≤0.15%, total impurities ≤0.5%, bacterial endotoxins <0.5 EU/mg, moisture ≤3.0%. These key indicators exceed to international pharmacopoeia requirements and can meet the production needs of high-safety anti-tumor preparations such as injections and sustained-release microspheres.
Octreotide powder is a white or off-white loose lyophilized powder, odorless and non-caking, with excellent water solubility. It dissolves quickly in water for injection and buffer systems with clear re-dissolution without foreign matters, facilitating formulation preparation and sterile filtration. The product has uniform crystal form, uniform particle size distribution and stable fluidity. It is compatible with complex processes such as microsphere embedding, sustained-release drug loading and lyophilization molding. It has good stability with no significant decline in purity and potency within the shelf life.
Octreotide API can bind to somatostatin receptors (SSTR2/5) with high selectivity. Its inhibitory activity is significantly higher than that of natural somatostatin. The half-life is extended to 1.5–2 hours, and that of long-acting preparations can reach 4–6 weeks.
Full-Cycle Quality Control & Consistent Quality
Full-Process Traceability Management
We cooperate with internationally certified partner factories to implement full-chain traceability management for Octreotide API, covering starting materials, peptide synthesis, cleavage and purification, lyophilization, sterile sieving, sub-packaging, packaging and finished product inspection. Each batch of product is assigned a unique batch number, and the production process is recorded in real time to achieve full traceability, verification and retesting.
Strict Standard and Compliance Assurance
Octreotide API (CAS 83150-76-9) is produced in strict accordance with ICH Q7, GMP, USP, EP and CP standards. A special testing scheme for anti-tumor polypeptides is implemented, covering full-dimensional tests such as structure confirmation, assay, related substances, residual solvents, elemental impurities, microbial limit, bacterial endotoxin, clarity and pH value. Quality indicators are fully aligned with international mainstream pharmacopoeias, supporting drug registration in major global markets including China, the United States, Europe and Japan. We provide compliant and stable Octreotide API supply for pharmaceutical companies and reduces registration and production risks.
Continuous Quality System Optimization
Supported by continuous technological upgrading of partner factories, we constantly optimize the synthesis and purification process of Octreotide API to improve product purity and yield while reducing impurity level and Octreotide cost. We have established a complete system for deviation handling, change control, stability inspection and annual quality review. Process verification and international benchmarking are carried out regularly to ensure consistent and stable quality of each batch, providing customers with long-term and reliable raw material support.
Application Scenarios
Octreotide API is only used as an active pharmaceutical ingredient and must be manufactured into medicinal products through formulation processes before clinical use. The core application scenarios are as follows.
Neuroendocrine Tumor Therapeutic Drugs
Preparations made from Octreotide have a remission rate of ≥80% for neuroendocrine tumor-related symptoms (flushing, diarrhea, abdominal pain) and a tumor growth control rate of ≥65%. They can effectively reduce the invasion and metastasis risk of gastroenteropancreatic tumors and are well tolerated by advanced patients. With low systemic exposure, adverse reactions are mainly mild to moderate gastrointestinal reactions with an incidence rate <8%. It has reliable long-term safety and provides stable clinical benefits for tumor patients.
Tumor-Related Emergency and Symptom Control Drugs
Preparations made from Octreotide API can be used to control critical emergencies such as intractable diarrhea, vomiting, gastrointestinal bleeding, pancreatic fistula and intestinal fistula caused by malignant tumors, especially for palliative treatment of advanced tumor patients. They can quickly relieve symptoms, reduce complication risks and create conditions for comprehensive treatment.
Adjuvant Therapeutic Drugs for Gastroenteropancreatic Tumors
Drugs prepared with Octreotide powder as the core raw material can be used for adjuvant therapy of solid tumors such as gastric cancer, colorectal cancer and pancreatic cancer. By inhibiting angiogenesis and hormone-driven pathways, they can reduce postoperative recurrence risk, improve chemoradiotherapy sensitivity and enhance the overall therapeutic effect.
R&D of Anti-Tumor Innovative Preparations
With high receptor selectivity and good safety, Octreotide API can be used in the R&D of innovative drugs such as long-acting sustained-release preparations, targeted preparations, radioactive conjugates and compound anti-tumor drugs. It has broad expansion potential in the fields of precision therapy and radionuclide integrated diagnosis and treatment, providing high-quality raw material support for the development of anti-tumor new drugs.
Packaging and Transportation
Octreotide API is vacuum-sealed in pharmaceutical-grade low-adsorption special peptide bottles/aluminum foil bags with built-in desiccant and light-proof materials. It is equipped with thermal insulation and shock-proof outer packaging, which has the properties of light protection, moisture protection, oxidation resistance, degradation resistance and pollution resistance to maximize the stability of peptide raw materials. Customized packaging service is also supported.
Logistics strictly implements pharmaceutical logistics and cold-chain transportation standards with full-process 2–8℃ low temperature and light protection. International transportation complies with UN regulations and cold-chain requirements, providing air freight and international express with full-process temperature monitoring and trackable routes for safe and on-time delivery. We have complete export qualifications, customs clearance documents and freight forwarding resources to ensure efficient and compliant global logistics services.
Our Advantages
Reasonable Pricing and Global Supply
Octreotide price is calculated transparently according to specifications and purchase volume with tiered pricing. Bulk Octreotide orders qualify for preferential pricing which can meet industrial mass production needs. Stable production capacity ensures sustainable supply for global customers. For specific quotations, please consult business representatives.
R&D Support and Customized Services
We can provide Octreotide Free Sample for potential R&D customers, which is suitable for prescription screening, testing method development, pharmacological preliminary experiments and other early R&D scenarios. The sample purity and quality are consistent with bulk goods. We also provide customized technical support to meet the needs of differentiated preparation development.
FAQ
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