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Suzetrigine API (CAS 2649467-58-1) is a first-in-class, highly selective NaV1.8 inhibitor API engineered for acute pain management. It acts by precisely blocking peripheral pain signals, with no risk of addiction or central nervous system depression. Delivering reliable analgesia with superior safety, it serves as an innovative non-opioid solution for moderate to severe acute pain indications.
Technical Specifications
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Product Name |
Suzetrigine API |
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Synonyms |
Suzetrigine Powder, Suzetrigine Raw Material |
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Characteristics |
A White to light yellow crystalline powder. |
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CAS Number |
2649467-58-1 |
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Assay |
≥99.0% (HPLC, Subject to the COA) |
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Formula |
C21H20F5N3O4 |
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Package |
Technical Package |
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Storage |
Short-term / Shipping: Store at 2–8 °C, sealed, protected from light and dry. Long-term: Store at ≤-20 °C, sealed, protected from light and dry. Stock Solution: Aliquot and store at -80 °C for 6 months or -20 °C for 1 month; avoid repeated freeze-thaw cycles. |
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Structure |
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As a leading China High Purity Suzetrigine API manufacturer and China Suzetrigine Powder supplier, we produce Suzetrigine API (CAS 2649467-58-1) in strict compliance with global GMP standards. Our full-process quality control ensures high purity, stable physicochemical properties, and exceptional batch-to-batch consistency. As a key NaV1.8 channel inhibitor Suzetrigine raw material, it fully supports oral analgesic R&D, formulation development, and clinical trials across all stages, providing solid support for innovative drug projects in acute pain therapy.
Product Features
Suzetrigine API targets peripheral pain neurons via allosteric binding of NaV1.8 channels, blocking pain signal transmission without crossing the blood–brain barrier. This non-opioid mechanism eliminates addiction and respiratory depression risks, establishing a novel safe pathway for pain management.
Suzetrigine Powder meets ≥99.0% purity (HPLC) with stable properties and consistent batch performance, fully satisfying international high standards for API R&D and production.
Suzetrigine Raw Material appears as a white to off-white crystalline solid, with excellent oral bioavailability and stable physicochemical traits. It supports the entire oral formulation development pipeline, from preclinical research to commercial production, delivering outstanding druggability for clinical applications.
Clinical data confirms Suzetrigine API's analgesic effect equals that of opioids with lower adverse reaction rates and higher safety. It is widely applicable to postoperative pain, acute trauma, and other moderate to severe acute pain scenarios, providing core raw material support for innovative pain management R&D.
Full-Cycle Quality Control & Consistent Quality
Suzetrigine API production adheres to global GMP standards, with standardized control from raw material procurement to finished product release. Full records and audit trails ensure compliant, controllable, and traceable manufacturing.
A multi-dimensional quality system covers purity, related substances, and stability testing via HPLC; each batch includes a COA to meet international pharmacopoeia-grade standards.
Through optimized synthesis and parameter control, High Purity Suzetrigine Powder achieves minimal fluctuations in key attributes (purity, crystal form, dissolution), ensuring stable supply for formulation and clinical needs.
We also offer a full life-cycle traceability system, with real-time monitoring of storage and transportation to maintain end-to-end quality stability.
Application Scenarios
With non-addictive, highly selective analgesic properties and strong druggability, Suzetrigine API suits diverse pain management fields:
Postoperative analgesia:
Develop oral formulations to block peripheral pain signals, effectively relieving moderate to severe surgical trauma pain and reducing central side effects and addiction concerns.
Acute trauma care:
Non-opioid analgesic drugs based on Suzetrigine Powder provide rapid pain relief for bruises, fractures, and acute trauma, avoiding opioid-related respiratory depression for safe emergency care.
Chronic neuropathic pain:
High Purity Suzetrigine API's high NaV1.8 selectivity supports chronic neuropathic pain drug development, offering long-term, non-addictive relief for conditions like diabetic peripheral neuralgia.
Minimally invasive outpatient settings:
Oral formulations enable rapid onset and safety, supporting same-day discharge and improving clinical experience for dental and minimally invasive procedures.
Innovative drug R&D: As a first-in-class NaV1.8 inhibitor, Suzetrigine Raw Material underpins preclinical, clinical, and commercial development of novel non-opioid analgesics, driving industry iteration.
Packaging and Transportation
We provide a standardized packaging and transportation system to ensure quality consistency:
Suzetrigine Powder uses pharmaceutical-grade sealed packaging (moisture-proof/light-proof inner bags + rigid outer containers) to isolate moisture, light, and physical impacts.
GMP-compliant packaging processes include cleanroom execution and material compatibility verification, with clear labeling for full traceability.
Temperature-controlled, shockproof transportation with real-time humidity monitoring supports land/air logistics, ensuring consistent quality upon delivery.
Customized packaging (research to industrial scales) and complete documentation (transport papers, COA) meet global import/export and storage standards.
Our Advantages
Core Technology
In-house mastered key synthesis technologies with iterative process.
optimization, enabling high-purity, stable production and efficient scaling, leading in cost-effectiveness and technical barriers.
Quality Control
Professional technical teams provide one-on-one support, flexible.
specification customization, and complete technical documents to meet diverse project needs.
Customization Service
Continuous R&D optimization of synthesis and purification processes improves yield and quality, with leading expertise in Nav1.8 target inhibitor APIs.
Supply Chain
Stable upstream/downstream integration with sufficient raw material reserves and flexible scheduling ensures long-term stable supply, supported by professional logistics to mitigate project risks.
FAQ
We prioritize quality and clinical safety, supplying high-purity, stable Suzetrigine API (CAS 2649467-58-1) with fully compliant, traceable production. Whether for early-stage R&D, formulation verification, or bulk Suzetrigine API orders, we deliver reliable support for diverse projects. We welcome global partners to advance safe analgesic innovation and build long-term, win-win collaborations.
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