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Semaglutide Injection (CAS 910463-68-2) is a human glucagon-like peptide-1 (GLP-1) analog produced by recombinant DNA technology using Saccharomyces cerevisiae. As a next-generation long-acting GLP-1 receptor agonist polypeptide, it features once-weekly dosing, glucose-dependent hypoglycemic mechanism, and significant cardiovascular benefits, making it a blockbuster drug for type 2 diabetes and long-term weight management.
If you are searching for China Semaglutide Injection manufacturers, our GMP-certified facility offers reliable supply. You can buy Semaglutide Injection directly from our factory with full quality documentation. Many customers also look for semaglutide injection online – we provide secure global shipping and regulatory support.
Technical Specifications
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Product Name |
Semaglutide Injection |
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Synonyms |
ozempic shot weight loss,semaglutide tablets |
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Characteristics |
Practically colorless or nearly colorless, clear isotonic liquid |
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CAS Number |
910463-68-2 |
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Assay |
≥98.5% (HPLC, Subject to the COA) |
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Formula |
C187H291N45O59 |
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Package |
Technical Package |
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Storage |
Store at 2~8℃ |
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Structure |
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As a trusted China Semaglutide Injection supplier, we keep Semaglutide Injection in stock for prompt delivery. Bulk Semaglutide Injection orders are welcome for both API and finished dosage forms.
Product Features

Long-acting, once-weekly dosing
Through molecular modification (introduction of Aib at position 8 to resist DPP-4 degradation, and attachment of C18 fatty diacid chain at Lys26 for albumin binding), the half-life is extended to ~7 days, enabling once-weekly administration with steady plasma concentration and high patient compliance.

Glucose-dependent hypoglycemia with very low risk of hypoglycemia
Stimulates insulin secretion and suppresses glucagon release only when blood glucose is elevated, effectively avoiding hypoglycemia. In Chinese T2DM patients, HbA₁c reduction up to 1.8% and target rate (<7.0%) up to 86.1%.
Significant weight loss and multiple metabolic benefits: Suppresses appetite, increases satiety, delays gastric emptying. In the STEP UP trial, 7.2 mg once-weekly achieved mean weight loss of 20.7%, with ~1/3 of participants achieving ≥25% weight loss. Also improves systolic/diastolic BP, triglycerides, and CRP.
Clear cardiovascular protection: SUSTAIN 6 showed 26% reduction in MACE and 39% reduction in non-fatal stroke. SELECT trial extended benefit to non-diabetic obese individuals with CVD (20% MACE reduction).
Stable physicochemical properties: Clear isotonic liquid, pH 7.4, excellent water solubility. Available as both injection and oral tablet, supporting different formulation routes.
Full-Cycle Quality Control & Consistent Quality
- End-to-end traceability: Microbial fermentation using genetically engineered Saccharomyces cerevisiae, followed by extraction, purification, and chemical modification. HPLC, MS, NMR are used for molecular weight, purity, and structure confirmation. Each batch has a unique lot number with real-time production records.
- Strict standards compliance: RP-HPLC purity >99.0%, stringent control of high molecular weight proteins, bacterial endotoxins, residual DNA, and host cell proteins. Fully compliant with CP, USP, EP, and ICH Q7. Some suppliers have completed FDA DMF filing.
- Continuous quality improvement: Annual process validation, deviation handling, change control, stability studies, and annual quality reviews ensure batch-to-batch consistency.
When you buy Semaglutide Injection for clinical or commercial use, our product is Semaglutide Injection made in China with global regulatory acceptance.
Application Scenarios
Semaglutide Injection is widely used in the following clinical and R&D fields:

Type 2 diabetes glycemic control
For adults with T2DM inadequately controlled on diet/exercise plus metformin and/or sulfonylureas. Once-weekly subcutaneous injection starting at 0.25 mg, titrated to 0.5 mg or 1 mg. SUSTAIN series trials (including 605 Chinese patients) confirmed excellent efficacy and safety.
Reducing cardiovascular event risk
Indicated for T2DM adults with established CVD to reduce MACE (cardiovascular death, non-fatal MI, or non-fatal stroke). SELECT trial extended benefit to non-diabetic obese/overweight individuals with CVD. STRIDE trial showed ankle-brachial index improvement of 5% in PAD patients after 52 weeks.
Long-term weight management
The weight-loss version (Wegovy®) is the first and only once-weekly GLP-1 receptor agonist for chronic weight management. 2.4 mg once-weekly for 68 weeks achieved ~14.9% mean weight loss (50.5% achieved ≥15%, 32% achieved ≥20%). In March 2026, FDA approved Wegovy® HD (7.2 mg once-weekly) with 20.7% mean weight loss.
MASH drug development
2025 post-hoc analysis showed semaglutide 2.4 mg can alleviate liver injury and improve fibrosis in MASH patients, independent of weight loss level.
Generic and innovative drug development
Clear mechanism and mature safety data support development of long-acting, sustained-release, and combination formulations. Full compliance with EP/USP helps shorten generic R&D cycles and reduce filing risks.
Packaging and Transportation
Professional packaging: API stored at ≤-15°C (stable for 18 months); after reconstitution, stable for 1 month at 2-8°C under aseptic conditions. Finished injection stored at 2-8°C, protect from light, do not freeze. Custom packaging available (milligram sealed vials for R&D, kilogram sealed drums for industrial use). All packages are labeled with product info, batch number, expiry date, and storage conditions.
Compliant cold chain logistics: Temperature-monitored cold chain with full traceability. Complete export qualifications, customs clearance documents, and freight forwarding resources enable fast, compliant delivery worldwide.
We understand semaglutide injection cost is a key concern for customers. As a direct factory, we offer competitive pricing. You can also buy semaglutide tablets buy online for oral formulation needs. Many customers search for semaglutide injections online – we provide secure, trackable shipping with regulatory documentation.
Our Advantages
High-standard quality assurance
From GMP-certified facility, RP-HPLC purity >99.0%, strict impurity control. Each batch includes complete test report (COA, HPLC, MS, NMR, high molecular weight proteins, endotoxins, residual DNA, stability data). Some suppliers have completed FDA DMF filing.
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Flexible supply & global service
Milligram to kilogram scales, strong stock availability. We offer Customized Semaglutide Injection (purity, particle size, packaging). Our 7×12 hour multilingual support ensures fast response. Bulk Semaglutide Injection is available for large-scale production.
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R&D support & free sample
We provide Semaglutide Injection Free Sample for formulation screening, method development, and preclinical trials–sample quality is identical to commercial batches. Also available: semaglutide tablets buy online for oral formulation R&D.
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Full regulatory documentation package
Complete dossier including COA, HPLC/MS/NMR spectra, high molecular weight protein analysis, related substances, bacterial endotoxins, microbial limits, residual DNA/proteins, stability data, and process summary–supporting global registrations in China, US, EU, Japan, Southeast Asia, etc.
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As a leading China Semaglutide Injection factory, we also supply other GLP-1 analogs. Semaglutide Injection made in China from our plant is trusted by pharmaceutical companies worldwide.
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FAQ
For inquiries about Semaglutide Injection, semaglutide injection online, or to request a Semaglutide Injection Free Sample, please contact us. We are your reliable China Semaglutide Injection supplier offering competitive semaglutide injection cost and professional service.
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